With optics positioned beneath the stage, inverted microscopes are commonly applied in the fields of life-science research. Gravity makes samples sink to the bottom of a holder when suspended in an aqueous solution, making it challenging to see crucial details from above. Because of this, you will often find researchers using inverted microscopes for cell culture imaging.
As the optics of the inverted microscope are located below the stage, users have a greater working distance, allowing for larger, heavier samples (up to 30kg in some instances) without crashing the objective and damaging sensitive components. This makes inverted microscopes suitable for industrial use in addition to life-science research applications. Inverted microscopes can also help speed up your workflow by allowing you to quickly and easily place your samples to begin examining them.
High-quality inverted microscopes often come with an upper focus stop functionality that provides additional security by defining the upper limit of the nosepiece. With this feature in place, you can protect your investment, focus on your task at hand and spend far less time worrying about the possible damage to your equipment and sample.
Inverted microscopes are available with brightfield transmitted/incident (bottom) illumination, phase contracts, and epi-fluorescence techniques. Epi-fluorescence is especially suited for viewing specimens on slides and metallurgical applications.
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